May 21 - Eastern Orthodox Church calendar - May 23
All fixed commemorations below celebrated on June 4 by Orthodox Churches on the Old Calendar.
For May 22nd, Orthodox Churches on the Old Calendar commemorate the Saints listed on May 9.
Commemoration of the Holy Fathers of the Second Ecumenical Council (381)
Righteous Melchizedek, King of Salem (ancient Jerusalem) (c. 2000 BC)
Martyr Sophia the Healer, a physician, by beheading.
Martyr Marcellus, by being placed in molten lead.
Martyr Codratus (Quadratus), by being dragged by horses. (see also: March 10)
Martyr Basiliscus of Comana (c. 308) (see also: March 3)
Hieromartyrs Donatus, Bishop of Thmuis, the priest Macarius, and the deacon Theodore (c. 316)
Saint John Vladimir, King of Serbia, Martyr, Wonderworker, whose relics are at Elbasan (1015)
Saint Ausonius, first Bishop of Angoulême (1st or 3rd century)
Saint Marcian of Ravenna, Bishop and Confessor (c. 127)
Martyrs Castus and Emilius, by fire, in Carthage (250)
Martyrs Timothy, Faustinus and Venustus, in Rome, under Julian the Apostate (362)
Saint Helen of Caernarfon (Elen Luyddog, lit. "Helen of the Hosts"), daughter of a Romano-British ruler, wife of Emperor Magnus Maximus, and a founder of churches in Wales (late 4th-century)
Saint Helen of Auxerre (c. 418)
Saint Julia of Corsica the martyr, who was crucified (440)