Louis II of Zweibrücken (German: Pfalzgraf Ludwig II. von Zweibrücken-Neuburg "der Jüngere") (14 September 1502 – 3 December 1532) was Count Palatine and Duke of Zweibrücken from 1514 to 1532.
He was the son of Alexander, Count Palatine of Zweibrücken (1462–1514) and his wife Countess Margarete of Hohenlohe-Neuenstein (1480–1522).
He was married in 1525 to Elisabeth of Hesse, daughter of William I, Landgrave of Lower Hesse, and they had two children. His son Wolfgang inherited the title and his daughter Christine died young in 1534.
Louis II died on 3 December 1532 and was buried in the crypt of Alexanderskirche (a church named for his father, who funded the original construction) in Zweibrücken.
Die Genealogie der Wittelsbacher