Jonathan Tyler Lester (born January 7, 1984) is an American former professional baseball pitcher. He played in Major League Baseball (MLB) for the Boston Red Sox, Oakland Athletics, Chicago Cubs, Washington Nationals, and St. Louis Cardinals. Less than two years after being diagnosed with lymphoma, Lester started and won the final game of the 2007 World Series for the Red Sox and, in May 2008, pitched a no-hitter against the Kansas City Royals. He helped lead the Red Sox to another championship in 2013, and he won the 2016 World Series with the Cubs. Lester started the opening game of a playoff series 12 times, which was a record for the most in baseball history until Justin Verlander passed him in 2023.
Lester attended Bellarmine Preparatory School in Tacoma, Washington. Playing for the school's baseball team, Lester was a three-time MVP and three-time All-Area selection. In addition, he was named Gatorade State Player of the Year for Washington in 2000.
The Red Sox selected Lester in the second round, with the 57th overall selection, of the 2002 Major League Baseball draft and gave him the highest signing bonus of any second-rounder that year, $1 million.
Lester quickly moved through the Red Sox organization, posting an 11–7 win–loss record, a league-leading 2.61 earned run average (ERA) and a league-best 163 strikeouts for the Portland Sea Dogs of the Class AA Eastern League in 2005. He was named the Eastern League Pitcher of the Year and Red Sox Minor League Pitcher of the Year and was selected as the left-handed pitcher on the Eastern League's year-end All-Star team and on the year-end Topps Class AA All-Star squad.
Lester was one of the Red Sox' top-rated prospects while in the minors, and other major league teams made efforts to acquire him. The Texas Rangers had demanded Lester be part of the proposed but ultimately rejected deal before the 2004 season for Alex Rodriguez. The Florida Marlins insisted he be included in the trade for Josh Beckett before the 2006 season, but again, the Sox were able to keep Lester.
With a rash of injuries and general ineffectiveness of several Red Sox starters, the team recalled Lester on June 10 to make his major league debut against the Texas Rangers. He put up a 7–2 record and a 4.76 ERA in 81+1⁄3 innings pitched in his rookie year.
On August 27, 2006, Lester was scratched from his scheduled start against the Oakland Athletics due to a sore back. The following day he was placed on the 15-day disabled list, and was sent back to Boston for testing. At the time, Lester's back problems were thought to be the result of a car crash he was involved in earlier in the month. On August 31, it was reported that Lester had been diagnosed with enlarged lymph nodes and was being tested for a variety of ailments, including forms of cancer. A few days later, doctors at Massachusetts General Hospital confirmed that Lester had a treatable form of anaplastic large cell lymphoma. Lester underwent off-season chemotherapy treatments at Seattle's Fred Hutchinson Cancer Research Center. In December 2006, ESPN.com reported that Lester's latest CT Scan showed no signs of the disease, which appeared to be in remission.
Following the successful treatment of his lymphoma, Lester was able to return to the Red Sox midway through the 2007 season. Lester attended spring training in 2007, and started the season for the class A Greenville Drive. Lester then started for Triple-A Pawtucket Red Sox in late April 2007. In June, Lester was removed from the disabled list, and sent to Pawtucket for further rehab outings.
Lester made his first 2007 start for the Boston Red Sox on July 23 against the Cleveland Indians at Jacobs Field in Cleveland, pitching six innings, allowing two runs on five hits and struck out six, picking up the win. On September 26 against the Oakland Athletics at Fenway Park, Lester gave up what would turn out to be the final career home run by Hall of Fame catcher Mike Piazza. In the 2007 World Series against the Colorado Rockies, Lester won the series-clinching Game 4 for the Red Sox, pitching 5+2⁄3 shutout innings, giving up three hits and three walks while collecting three strikeouts. Lester became the third pitcher in World Series history to win a series clinching game in his first post-season start.
To honor Lester's comeback from lymphoma, the Boston Baseball Writers' Association of America voted him the 2007 Tony Conigliaro Award.
On May 19, 2008, Lester threw a no-hitter in a 7–0 win against the Kansas City Royals. It was the 18th no-hitter in Red Sox history. Lester threw 130 pitches in the game, allowing only two walks and striking out nine batters, and was charged with a throwing error on a pickoff attempt in the second inning. It was the first no-hitter thrown by a Red Sox left-handed pitcher since Mel Parnell in 1956, the first in MLB since teammate Clay Buchholz in September 2007, and the MLB-record fourth no-hitter caught by Jason Varitek. It was also only the second no-hitter ever pitched against the Royals; Nolan Ryan pitched the other in 1973.
In 2008, Lester went 16–6 with a 3.21 ERA. Along with his no-hitter, he pitched a five-hit shutout in his first start at Yankee Stadium. He was named the AL Pitcher of the Month in July and September. Lester was also a key figure in the Red Sox' victory over the Angels in the American League Divisional Series, pitching 14 innings without allowing an earned run. Lester had the second highest winning percentage of all starting pitchers over the last three years (27–8, .771), and led the Red Sox in innings pitched in 2008 with 210+1⁄3.
Lester's losses in Games 3 and 7 of the 2008 ALCS were the first losses he had ever had in consecutive starts.
Lester also received the 2008 Hutch Award, given to the Major League player who "best exemplifies the fighting spirit and competitive desire" of Hutchinson.
On March 8, Lester agreed to a five-year, $30 million contract extension with a $14 million team option in 2014.
The season started poorly, with him allowing 11 runs and getting losses in his first two starts. This was the first time he lost in consecutive regular season starts. He began to pitch very well in late May, going 12–3 with a 2.31 ERA in his final 22 starts.
On June 6, Lester made his bid for a second no-hitter against the AL West-leading Texas Rangers at Fenway. He pitched 61⁄3 perfect innings, striking out 10 batters on 61 pitches through the first six innings. Michael Young hit a one-out double to left center field in the seventh inning to break up the no-hitter, but Lester pitched a complete game, striking out a total of 11 batters, giving him 23 strikeouts in two starts (he had a career-best 12 strikeouts his previous start). On August 14, Lester struck out ten batters for the sixth time in the 2009 season, the most times ever by a Red Sox left-handed pitcher. He had never done it before that season. Lester started 32 games in 2009, going 15–8 with a 3.41 ERA.
Lester started Game 1 of the 2009 ALDS against the Los Angeles Angels of Anaheim, but the Red Sox lost the game 5–0 and would eventually be swept in the series.