Ioannis Palaiokrassas (Greek: Ιωάννης Παλαιοκρασσάς; 27 March 1934 – 2 October 2021) was a Greek politician.
He participated in the parliamentary committee that investigated Andreas Papandreou and his minister in the Koskotas scandal.
He was a Minister for Finance and a European Commissioner in the Delors Commission. On 14 July 1992 Palaiokrassas's car was the target of a rocket attack by November 17 in Central Athens. The attack missed its target, but killed a passer-by.
He was the chairman of the board at Logos University College.
On 2 October 2021, Palaiokrassas died at the age of 85.