Giacomo Gentilomo (5 April 1909 – 16 April 2001) was an Italian film director and painter.
He was born in Trieste. Gentilomo moved to Rome at a young age.
At 21 years old he entered the cinema industry, working as a script surveyor and an assistant director. Active between 1933 and 1937 as a film editor, in 1939 he debuted as a director with Il Carnevale di Venezia. His 1945 film O sole mio got critical acclaim. His later career was mainly devoted to genre films, and failed to achieve significant critical interest. Dissatisfied with cinema, in the mid-1960s Gentilomo decided to abandon films and to instead fulfill his passion for painting.