Clemens Peter Freiherr von Pirquet (12 May 1874 – 28 February 1929) was an Austrian scientist and pediatrician best known for his contributions to the fields of bacteriology and immunology.
Born in Vienna, he studied theology at the University of Innsbruck and philosophy at the University of Leuven before he enrolled at the University of Graz where he became a doctor of medicine in 1900. He started practicing at the Children's Clinic in Vienna.
In 1906 he noticed that patients who had previously received injections of horse serum or smallpox vaccine had quicker, more severe reactions to a second injection. He coined the word allergy (from the Greek allos meaning "other" and ergon meaning "work") to describe this hypersensitivity reaction.
Soon after, the observation with smallpox led Pirquet to realize that tuberculin, which
Robert Koch isolated from the bacteria that cause tuberculosis in 1890, might lead to a similar type of reaction. Charles Mantoux expanded upon Pirquet's ideas and the Mantoux test, in which tuberculin is injected into the skin, became a diagnostic test for tuberculosis in 1907.
In 1909 he declined proposals to take a position at the Pasteur Institute in Paris and to become a professor at the Johns Hopkins University. In 1910 he returned to Europe taking positions in Breslau (now Wrocław) and then Vienna.
On 28 February 1929 Clemens von Pirquet and his wife committed suicide with potassium cyanide.
U.S. National Library of Medicine – History of medicine
Arthur M. Silverstein, Clemens Freiherr von Pirquet: Explaining immune complex disease in 1906 (Nature – Immunology 1, p.453–455, 2000)
EAACI – Clemens von Pirquet FOUNDATION
Clemens von Pirquet, Allergie 1910
Huber, Benedikt (2006), "[100 years of allergy: Clemens von Pirquet--his concept of allergy and his basic understanding of the disease: 2: The Pirquet concept of allergy]" (PDF), Wien. Klin. Wochenschr., vol. 118, no. 23–24 (published Dec 2006), pp. 718–27, doi:10.1007/s00508-006-0712-0, PMID 17186166, S2CID 40283841
Huber, Benedikt (2006), "[100 years of allergy: Clemens von Pirquet - his idea of allergy and its immanent concept of disease]" (PDF), Wien. Klin. Wochenschr., vol. 118, no. 19–20 (published Oct 2006), pp. 573–9, doi:10.1007/s00508-006-0701-3, PMID 17136331, S2CID 46144926
Bergmann, K C (2006), "[Clemens Freiherr von Pirquet, developer of the concept of allergy]", MMW Fortschritte der Medizin, vol. 148, no. 29–30 (published Jul 20, 2006), pp. 24–5, 27, PMID 16910402
Bukantz, Samuel C (2002), "Clemens von Pirquet and the concept of allergie", J. Allergy Clin. Immunol., vol. 109, no. 4 (published Apr 2002), pp. 724–6, doi:10.1067/mai.2002.123049, PMID 11980437
Slavin, R G (1982), "The 10th annual Clemens von Pirquet lectureship. Clinical disorders of the nose and their relationship to allergy", Annals of Allergy, vol. 49, no. 3 (published Sep 1982), pp. 123–6, PMID 7051906
Bendiner, E (1981), "Baron von Pirquet: the aristocrat who discovered and defined allergy", Hosp. Pract. (Off. Ed.), vol. 16, no. 10 (published Oct 1981), pp. 137, 141, 144 passim, PMID 6800919
Wyklicky, H (1980), "[Thoughts on the history of allergy. In memoriam Clemens von Pirquet]", Wiener Medizinische Wochenschrift, vol. 130, no. 3 (published Feb 15, 1980), pp. 123–5, PMID 6989119