April 22 in Eastern Orthodox liturgical calendars is a feast day and a day of commemoration of saints and martyrs. Although some Orthodox churches use the Revised Julian Calendar and others use the traditional Julian calendar, the fixed commemorations for their respective April 22 are broadly the same, no matter which calendar is used.
Holy Apostle Nathaniel of the Twelve (Bartholomew) (1st century)
Apostles Apelles, Luke (not the Evangelist), and Clement, of the Seventy (1st century)
Martyr Leonides of Alexandria, Bishop (202)
Martyr Nearchus, by fire (3rd century)
Venerable Theodore the Sykeote, Bishop of Anastasiopolis in Galatia (613) (see also: June 15 - Translation; June 16 - Uncovering)
Saint Vitalis of Gaza, monk of the monastery of Abba Seridus at Gaza (609-620) (see also: January 11)
Hieromartyr Soter, Pope of Rome (c. 174)
Martyrs Epipodius of Lyons, by beheading (c. 177)
Saint Gaius, born in Dalmatia, became Pope of Rome, martyred with members of his family (296) (see also: August 11)
Saint Agapitus I, Pope of Rome (536) (see also: April 17 - East)
Saint Leo of Sens, Bishop of Sens in France for twenty-three years (541)
The Two Brothers Arwald, sons of Arwald, the last Jutish King of the Isle of Wight, put to death by soldiers of King Ceadwalla, then a pagan, on the day after their baptism (686)
Saint Opportuna of Montreuil, sister of St Chrodegang, Bishop of Séez, Abbess at the convent of Monteuil (c. 770)
Saint Senorina, a Galician abbess who served as the abbess of the Benedictine convent of St John of Venaria (Vieyra) (982)
Saint Ananias of Malles, first monk, renovator and Abbot of the Holy Monastery of Panagia Exakousti in the village of Malles in Ierapetra, Crete (1907)
Saint Ekaterina (Malkov-Panina), fool-for-Christ, of the Holy Dormition Pukhtitsa Convent in Estonia (1968)
New Hieromartyr Eustathius Malahovsky, Priest (1918)