Alexis Carrel (French: [alɛksi kaʁɛl]; 28 June 1873 – 5 November 1944) was a French surgeon and biologist who spent most of his scientific career in the United States. He was awarded the Nobel Prize in Physiology or Medicine in 1912 for pioneering vascular suturing techniques. He invented the first perfusion pump with Charles Lindbergh opening the way to organ transplantation. In later time however, it was acknowledged that Carrel and Lindbergh's version of the perfusion pump, which initially had media prominence, was impractical and difficult to use, and would lose influence by the 1940s. Carrel was also a pioneer in tissue culture, transplantology and thoracic surgery. He is known for his leading role in implementing eugenic policies in Vichy France.
Born in Sainte-Foy-lès-Lyon, Rhône, Carrel was raised in a devout Catholic family and was educated by Jesuits, though he had become an agnostic by the time he became a university student. He studied medicine at the University of Lyon.
Working as an intern at a Lyon hospital, he developed a technique for suturing small blood vessels using extremely fine needles. He published his first scientific article about this method in 1902.
In 1902, Carrel underwent a transformative experience that led him from being a skeptic of the reported visions and miracles at Lourdes to a believer in spiritual cures. This conversion came about after he witnessed the inexplicable healing of Marie Bailly, who then identified Carrel as the principal witness of her cure. Despite facing opposition from his peers in the medical community, Carrel refused to dismiss a supernatural explanation for the event. His beliefs proved to be a hindrance to his career and reputation in academic medicine in France, and as a result he left France for Canada. Carrel would write a book about the case The Voyage to Lourdes, which was released four years after his death.
Shortly after arriving in Canada, he accepted a position at the University of Chicago. While there he collaborated with American physician Charles Claude Guthrie in work on vascular suture and the transplantation of blood vessels and organs as well as the head. Carrel would be awarded the 1912 Nobel Prize in Physiology or Medicine for these efforts.
In 1906, he joined the newly formed Rockefeller Institute of Medical Research in New York where he spent the rest of his career. There he did significant work on tissue cultures with pathologist Montrose Thomas Burrows.
In World War I, Carrel served as a major in the French Army medical Corps. During this time he developed the popular Carrel-Dakin method for treating wounds.
In the 1930s, Carrel and Charles Lindbergh became close friends not only because of the years they worked together but also because they shared personal, political, and social views. Lindbergh initially sought out Carrel to see if his sister-in-law's heart, damaged by rheumatic fever, could be repaired. When Lindbergh saw the crudeness of Carrel's machinery, he offered to build new equipment for the scientist. Eventually they built the first perfusion pump, an invention instrumental to the development of organ transplantation and open heart surgery. Lindbergh considered Carrel his closest friend, and said he would preserve and promote Carrel's ideals after his death. The pump received significant media hype, which included an appearance on the cover of the June 13, 1938 edition of Time and being exhibited at the 1939 World's Fair, where it was billed as being the "Lindbergh-Carrel mechanical heart" and served as one of the focal points of interest in the fair's Medicine and Public Health Buildings. Despite this, the American Academy of Cardiovascular Perfusion would acknowledge by 2017 that most researchers in fact found that Carrel and Lindbergh's perfusion pump, which was at times also called the "Lindbergh perfusion pump," to be "impractical and difficult to use," and that "by the early 1940s, the pump's time in the spotlight had run out." Carrel would be forced into retirement by the Rockefeller Institute and returned to his native country France.
In 1939, Carrel returned to France and took a position with the French Ministry of Health. Due to his close proximity with Jacques Doriot's fascist Parti Populaire Français (PPF) during the 1930s and his role in implementing eugenics policies during Vichy France, he was accused after the Liberation of collaboration, but died before the trial.
In his later life he returned to his Catholic roots. In 1939, he met with Trappist monk Alexis Presse on a recommendation. Although Carrel was skeptical about meeting with a priest, Presse ended up having a profound influence on the rest of Carrel's life. In 1942, he said "I believe in the existence of God, in the immortality of the soul, in Revelation and in all the Catholic Church teaches." He summoned Presse to administer the Catholic Sacraments on his death bed in November 1944.
For much of his life, Carrel and his wife spent their summers on the Île Saint-Gildas, which they owned. After he and Lindbergh became close friends, Carrel persuaded him to also buy a neighboring island, the Ile Illiec, where the Lindberghs often resided in the late 1930s.
Carrel was a young surgeon who was deeply affected by the 1894 assassination of the French president, Sadi Carnot, who died from a severed portal vein that surgeons believed was irreparable. This tragedy inspired Carrel to develop new techniques for suturing blood vessels, such as the "triangulation" technique using three stay-sutures to minimize damage to the vascular wall during suturing. Carrel learned this technique from an embroideress, and later incorporated it into his work. According to Julius Comroe, Carrel performed every feat and developed every technique in vascular surgery using experimental animals between 1901 and 1910, leading to his great success in reconnecting arteries and veins and performing surgical grafts. These achievements earned him the Nobel Prize in 1912.
During World War I (1914–1918), Carrel and the English chemist Henry Drysdale Dakin developed the Carrel–Dakin method of treating wounds with an antiseptic solution based on chlorine, known as Dakin's solution. This method, which involved wound debridement and irrigation with a high volume of antiseptic fluid, was a significant medical advancement in the absence of antibiotics. For his contributions, Carrel was awarded the Légion d'honneur. The Carrel–Dakin method became widely used in hospitals. The mechanical irrigation technique developed by Carrel is still used today.
Carrel co-authored a book with pilot Charles Lindbergh, The Culture of Organs. Together, they developed the perfusion pump in the mid-1930s, which made it possible for organs to remain viable outside of the body during surgical procedures. This innovation is considered to be a significant advancement in the fields of open-heart surgery and organ transplantation, and it paved the way for the development of the artificial heart, which became a reality many years later. Although some critics accused Carrel of exaggerating Lindbergh's contributions to gain publicity, other sources indicate that Lindbergh played a significant role in the device's development. In recognition of their groundbreaking work, both Carrel and Lindbergh appeared on the cover of Time magazine on June 13, 1938.
Tissue culture and cellular senescence
Carrel developed methods to keep animal tissues alive in culture. He was interested in the phenomenon of senescence or aging. He believed that all cells continued to grow indefinitely, which became a widely accepted view in the early 20th century. In 1912, Carrel began an experiment at the Rockefeller Institute for Medical Research, where he cultured tissue from an embryonic chicken heart in a stoppered Pyrex flask of his own design. He supplied the culture with nutrients regularly and maintained it for over 20 years, longer than a chicken's normal lifespan. This experiment received significant popular and scientific attention, but it was never successfully replicated.